Delivery of curcumin by shellac encapsulation: Stability, bioaccessibility, freeze-dried redispersibility, and solubilization.

ABSTRACT: Curcumin is an active ingredient with multiple functions, however, its application is limited by its low stability, bioaccessibility, freeze-dried redispersibility, and solubilization. The work aims to improve the application of curcumin (Cur) by encapsulation. Shellac was the wall material inspired by its pH-dependent deprotonation and amphiphilic nature to form nanoparticles. The curcumin/shellac nanoparticles (S/Cur) exhibited a bright spot of high loading capacity (the maximum of higher than 70 %), while still having high encapsulation efficiency (the minimum of higher than 85 %). Transmission electron microscopy showed that S/Cur was a spherical structure. It exhibited good physical stability, including pH (4.0-8.0), ionic strength (NaCl, < 900 mM), thermo stability (80 ℃, 180 min), a

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC9532768 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature