Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS.

ABSTRACT:

Background

Concerns remain about the human reproductive toxicity of the widespread per- and polyfluoroalkyl substances (PFAS) during early stages of development.

Objectives

We examined associations between maternal plasma PFAS levels during early pregnancy and male offspring reproductive function in adulthood.

Methods

The study included 864 young men (age range:18.9-21.2 y) from the Fetal Programming of Semen Quality (FEPOS) cohort established between 2017 and 2019. Plasma samples from their mothers, primarily from the first trimester, were retrieved from the Danish National Biobank and levels of 15 PFAS were measured. Seven PFAS had detectable levels above the limit of detection in >80% of the samples and were included in analyses. Semen quality, testicular volume, a

SUBMITTER: Hærvig KK 

PROVIDER: S-EPMC9533763 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature