Functional and biological heterogeneity of KRAS^Q61 mutations.

ABSTRACT: Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly¹², Gly¹³, and Gln⁶¹ (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61 mutations in KRAS are infrequent and differ markedly in occurrence. Q61H is the predominant mutant (at 57%), followed by Q61R/L/K (collectively 40%), and Q61P and Q61E are the rarest (2 and 1%, respectively). Probability analysis suggested that mutational susceptibility to different DNA base changes cannot account for this distribution. Therefore, we investigated whether these frequencies might be explained by differences in the biochemical, structural, and biological properties of KRAS^Q61 mutants. Expression of KRAS^Q61</

SUBMITTER: Huynh MV 

PROVIDER: S-EPMC9534304 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature