Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans.

ABSTRACT: Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection-induced pathways including cell cycle and interferon (IFN) signaling. TDRD7 is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species. TDRD7 is required for antiviral IFN res

SUBMITTER: Forst CV 

PROVIDER: S-EPMC9534503 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature