Olfactory marker protein regulation of glucagon secretion in hyperglycemia.

ABSTRACT: The olfactory marker protein (OMP), which is also expressed in nonolfactory tissues, plays a role in regulating the kinetics and termination of olfactory transduction. Thus, we hypothesized that OMP may play a similar role in modulating the secretion of hormones involved in Ca²⁺ and cAMP signaling, such as glucagon. In the present study, we confirmed nonolfactory α-cell-specific OMP expression in human and mouse pancreatic islets as well as in the murine α-cell line αTC1.9. Glucagon and OMP expression increased under hyperglycemic conditions. Omp knockdown in hyperglycemic αTC1.9 cells using small-interfering RNA (siRNA) reduced the responses to glucagon release and the related signaling pathways compared with the si-negative control. The OMP^lox/lox;GCG^cre/w

SUBMITTER: Oh JH 

PROVIDER: S-EPMC9534918 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature