Taste Impairments in a Parkinson's Disease Model Featuring Intranasal Rotenone Administration in Mice.

ABSTRACT:

Background

Taste impairments are often accompanied by olfactory impairments in the early stage of Parkinson's disease (PD). The development of animal models is required to elucidate the mechanisms underlying taste impairments in PD.

Objective

This study was conducted to clarify whether the intranasal administration of rotenone causes taste impairments prior to motor deficits in mice.

Methods

Rotenone was administrated to the right nose of mice once a day for 1 or 4 week(s). In the 1-week group, taste, olfactory, and motor function was assessed before and after a 1-week recovery period following the rotenone administration. Motor function was also continuously examined in the 4-weeks group from 0 to 5 weeks. After a behavioral test, the number of catecholamine neurons

SUBMITTER: Yin DX 

PROVIDER: S-EPMC9535587 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature