Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers.

ABSTRACT:

Background / synopsis

Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to peripheral cells. Little is known on the role, if any, of circulating lipid-related factors such as PCSK9, ANGPTL3 and lipoprotein (a) in cancers.

Objective/purpose

To compare circulating levels of PCSK9, ANGPTL3, and Lp(a) in women with stage III breast cancer versus women with premalignant or benign breast lesions.

Methods

Twenty-three plasma samples from women diagnosed with a stage III breast cancer (ductal, lobular or mixed) were matched for age with twenty-three plasma samples from women bearing premalignant (stage 0, n = 9) or benign (n

SUBMITTER: Wong Chong E 

PROVIDER: S-EPMC9535963 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature