Endogenous Circadian Clock Machinery in Cortical NG2-Glia Regulates Cellular Proliferation.

ABSTRACT: The molecular circadian clock can be found throughout the body and is essential for the synchronizing cellular physiology with the 24 h day. However, the role of the clock in regulating the regenerative potential of the brain has not been explored. We report here that murine NG2-glia, the largest population of proliferative cells in the mature central nervous system, rhythmically express circadian clock genes in a 24 h period, including the critical clock component Bmal1 RNA and BMAL1 protein. Interestingly, daily NG2-glia proliferation preferentially occurs during the time of day in which Bmal1 expression is high, while conditional knockout of Bmal1 decreases both cortical NG2-glia density and cellular proliferation. Furthermore, in a neurotrauma model, we show that p

SUBMITTER: Dean T 

PROVIDER: S-EPMC9536852 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature