Characterization of pathogen-inactivated COVID-19 convalescent plasma and responses in transfused patients.

ABSTRACT:

Background

Efficacy of donated COVID-19 convalescent plasma (dCCP) is uncertain and may depend on antibody titers, neutralizing capacity, timing of administration, and patient characteristics.

Study design and methods

In a single-center hypothesis-generating prospective case-control study with 1:2 matched dCCP recipients to controls according to disease severity at day 1, hospitalized adults with COVID-19 pneumonia received 2 × 200 ml pathogen-reduced treated dCCP from 2 different donors. We evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in COVID-19 convalescent plasma donors and recipients using multiple antibody assays including a Coronavirus antigen microarray (COVAM), and binding and neutralizing antibody assays. Outcomes were dCCP char

SUBMITTER: Weisser M 

PROVIDER: S-EPMC9538076 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature