Development of a wireless ultrasonic brain stimulation system for concurrent bilateral neuromodulation in freely moving rodents.

ABSTRACT: Bilateral brain stimulation is an important modality used to investigate brain circuits and treat neurological conditions. Recently, low-intensity pulsed ultrasound (LIPUS) received significant attention as a novel non-invasive neurostimulation technique with high spatial specificity. Despite the growing interest, the typical ultrasound brain stimulation study, especially for small animals, is limited to a single target of sonication. The constraint is associated with the complexity and the cost of the hardware system required to achieve multi-regional sonication. This work presented the development of a low-cost LIPUS system with a pair of single-element ultrasound transducers to address the above problem. The system was built with a multicore processor with an RF amplifier circuit. In ad

SUBMITTER: Kim E 

PROVIDER: S-EPMC9539445 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature