Salvage surgery in recurrent sinonasal cancers: Proposal for a prognostic model based on clinicopathologic and treatment-related parameters.
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ABSTRACT: Background
Evidence on survival and major prognosticators after salvage surgery in recurrent sinonasal cancers (SNC) is limited.Methods
A retrospective, single-center study of recurrent SNC treated with salvage surgery between 1997 and 2019 was conducted. Univariate and multivariable analyses were performed to define a prognostic score for overall survival (OS).Results
One hundred and eighteen patients were included. Recurrent SNC originated mostly in the naso-ethmoidal box (67.8%) and were mainly epithelial (76.2%), high-grade (49.2%), and locally advanced (rpT4, 60.1%) malignancies. Negative margins were achieved in 56.6% of cases. Two- and 5-year OS were 71.7% and 56%, respectively. The prognostic model included treatment modality for primary tumor, histology, rpT class, margin status, perineural invasion, and adjuvant radiotherapy and stratified patients into three prognostic groups (5-year OS: 84.4%, 44.9%, and 0%, respectively).Conclusions
Treatment of recurrent SNC can result in good long-term survival estimates with limited morbidity. Our score can provide excellent prognostic stratification.
SUBMITTER: Mattavelli D
PROVIDER: S-EPMC9539884 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Salvage surgery in recurrent sinonasal cancers: Proposal for a prognostic model based on clinicopathologic and treatment-related parameters.
Mattavelli Davide D Tomasoni Michele M Ferrari Marco M Compagnoni Alessandra A Schreiber Alberto A Taboni Stefano S Rampinelli Vittorio V Marazzi Elisa E Raffetti Elena E Redaelli de Zinis Luca Oscar LO Deganello Alberto A Maroldi Roberto R Bossi Paolo P Piazza Cesare C Nicolai Piero P
Head & neck 20220602 8
<h4>Background</h4>Evidence on survival and major prognosticators after salvage surgery in recurrent sinonasal cancers (SNC) is limited.<h4>Methods</h4>A retrospective, single-center study of recurrent SNC treated with salvage surgery between 1997 and 2019 was conducted. Univariate and multivariable analyses were performed to define a prognostic score for overall survival (OS).<h4>Results</h4>One hundred and eighteen patients were included. Recurrent SNC originated mostly in the naso-ethmoidal b ...[more]
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