Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity.

ABSTRACT:

Background

The early detection and management of children with metabolic associated fatty liver disease (MAFLD) is challenging.

Objective

To develop a non-invasive and accurate prediction protocol for the identification of MAFLD among children with overweight/obesity candidates to confirmatory diagnosis.

Methods

A total of 115 children aged 8-12 years with overweight/obesity, recruited at a primary care, were enrolled in this cross-sectional study. The external validation was performed using a cohort of children with overweight/obesity (N = 46) aged 8.5-14.0 years. MAFLD (≥5.5% hepatic fat) was diagnosed by magnetic resonance imaging (MRI). Fasting blood biochemical parameters were measured, and 25 candidates' single nucleotide polymorphisms (SNPs) were determined. Va

SUBMITTER: Oses M 

PROVIDER: S-EPMC9541234 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature