Shift in harms and benefits of cervical cancer screening in the era of HPV screening and vaccination: a modelling study.

ABSTRACT:

Objective

To calculate the changes in harms and benefits of cervical cancer screening over the first three screening rounds of the Dutch high-risk human papillomavirus (hrHPV) screening programme.

Design

Microsimulation study.

Setting

Dutch hrHPV screening programme; women are invited for screening every 5 or 10 years (depending on age and screening history) from age 30 to 65.

Population

Partly vaccinated population of 100 million Dutch women.

Methods

Microsimulation model MISCAN was used to estimate screening effects. Sensitivity analyses were performed on test characteristics and attendance.

Main outcome measures

Harms (screening tests, unnecessary referrals, treatment-related health problems), benefits (CIN2⁺ diagnoses) and programme

SUBMITTER: Kaljouw S 

PROVIDER: S-EPMC9541905 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature