Characterization of laboratory coagulation parameters and risk factors for intraventricular hemorrhage in extremely premature neonates.

ABSTRACT:

Background

Extremely premature neonates have increased risk for bleeding, perhaps the most devastating version of which being intraventricular hemorrhage (IVH). Limited data are available for coagulation parameters in this vulnerable population.

Objectives

We conducted a prospective cohort study characterizing coagulation laboratory parameters in extremely premature neonates 23-30 weeks gestational age (GA) and determined coagulation parameters and clinical risk factors associated with IVH.

Patients/methods

One hundred twenty neonates 23-30 weeks GA were enrolled, and umbilical cord blood samples were obtained and processed at the time of birth. Coagulation parameters including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplast

SUBMITTER: Roberts JC 

PROVIDER: S-EPMC9543331 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature