Sensitivity to Change and Patient-Centricity of the Unified Multiple System Atrophy Rating Scale Items: A Data-Driven Analysis.

ABSTRACT:

Background

The Unified Multiple System Atrophy Rating Scale (UMSARS) is a commonly used semiquantitative rating scale to assess symptoms and measure disease progression in multiple system atrophy (MSA). However, it is currently incompletely understood which UMSARS items are the most sensitive to change and most relevant to the patient.

Objective

The objective of this study was to assess sensitivity to change and patient-centricity of single UMSARS items.

Methods

Data were taken from the European Multiple System Atrophy Study Group Natural History Study and the Rasagiline for Multiple System Atrophy trial. Sensitivity of change of an item of the UMSARS was assessed by calculation of a sensitivity-to-change ratio using its mean slope of progression divided by the standa

SUBMITTER: Krismer F 

PROVIDER: S-EPMC9543676 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature