Early HIV treatment and survival over six years of observation in the ANRS 12249 Treatment as Prevention Trial.

ABSTRACT:

Objectives

Population-based universal test and treat (UTT) trials have shown an impact on population-level virological suppression. We followed the ANRS 12249 TasP trial population for 6 years to determine whether the intervention had longer-term survival benefits.

Methods

The TasP trial was a cluster-randomized trial in South Africa from 2012 to 2016. All households were offered 6-monthly home-based HIV testing. Immediate antiretroviral therapy (ART) was offered through trial clinics to all people living with HIV (PLHIV) in intervention clusters and according to national guidelines in control clusters. After the trial, individuals attending the trial clinics were transferred to the public ART programme. Deaths were ascertained through annual demographic surveillance. Random

SUBMITTER: Baisley K 

PROVIDER: S-EPMC9545558 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature