Similarity and consistency assessment of three major online drug-drug interaction resources.

ABSTRACT:

Aims

The aim of this study was to explore the level of agreement on drug-drug interaction (DDI) information listed in three major online drug information resources (DIRs) in terms of: (1) interacting drug pairs; (2) severity rating; (3) evidence rating; and (4) clinical management recommendations.

Methods

We extracted information from the British National Formulary (BNF), Thesaurus and Micromedex. Following drug name normalisation, we estimated the overlap of the DIRs in terms of DDI. We annotated clinical management recommendations either manually, where possible, or through application of a machine learning algorithm.

Results

The DIRs contained 51 481 (BNF), 38 037 (Thesaurus) and 65 446 (Micromedex) drug pairs involved in DDIs. The number of common DDIs across the

SUBMITTER: Kontsioti E 

PROVIDER: S-EPMC9545693 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature