Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets.

ABSTRACT:

Aim

The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets.

Methods

We used two data sets for East Asian (EAS) and European (EUR) samples. SCZ data was based on the Psychiatric Genomics Consortium Asia with our own genome-wide association study for EAS and Psychiatric Genomics Consortium for EUR. Nonpsychiatric data (20 binary traits [mainly nonpsychiatric complex disorders] and 34 quantitative traits [mainly laboratory examinations and physical characteristics]) were obtained from Biobank Japan and UK Biobank for EAS and EUR samples, respectively. To evaluate genetic correlation, linkage disequilibrium score regressio

SUBMITTER: Aoki R 

PROVIDER: S-EPMC9546074 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature