Metabolic Acidosis is Associated With Acute Kidney Injury in Patients With CKD.

ABSTRACT:

Introduction

Metabolic acidosis in patients with chronic kidney disease (CKD) results from a loss of kidney function. It has been associated with CKD progression, all-cause mortality, and other adverse outcomes. We aimed to determine whether metabolic acidosis is associated with a higher risk of acute kidney injury (AKI).

Methods

This was a retrospective cohort study. Using electronic health records and administrative data, we enrolled 2 North American cohorts of patients with CKD Stages G3-G5 as follows: (i) 136,067 patients in the US electronic medical record (EMR) based cohort; and (ii) 34,957 patients in the Manitoba claims-based cohort. The primary exposure was metabolic acidosis (serum bicarbonate between 12 mEq/l and <22 mEq/l). The primary outcome was the development

SUBMITTER: Zhu A 

PROVIDER: S-EPMC9546743 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature