Platelet Activity and Cardiovascular Risk in CKD and Peripheral Artery Disease.

ABSTRACT:

Introduction

Platelet dysfunction and cardiovascular risk are well-recognized features of chronic kidney disease (CKD). Platelets drive the development and progression of cardiovascular disease (CVD). The relationships between kidney function, platelet activity, and cardiovascular risk are poorly defined.

Methods

We compared platelet activity and incident cardiovascular events by CKD status (estimated glomerular filtration rate [eGFR] < 60 ml/min per 1.73 m²) using data from the Platelet Activity and Cardiovascular Events study, a prospective cohort study that enrolled adults with peripheral artery disease (PAD) undergoing lower extremity revascularization. Platelet activity was measured using light transmission aggregometry (LTA) in response to submaximal dose ag

SUBMITTER: Cofer LB 

PROVIDER: S-EPMC9546761 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature