Metabolic parameters on baseline ¹⁸F-FDG PET/CT are potential predictive biomarkers for immunotherapy in patients with head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

We evaluated baseline ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters for predicting prognosis in patients with head and neck squamous cell carcinoma (HNSCC) who were receiving immune checkpoint inhibitors (ICIs). In addition, we also investigated the relationships between immunohistochemical (IHC) biomarkers and metabolic parameters.

Materials and methods

A total of 39 patients with HNSCC who underwent ¹⁸F-FDG PET/CT prior to ICI therapy between November 2015 and December 2020 were enrolled. PET parameters of tumor lesions included standardized uptake values, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and spleen-to-liver ratio (SLR). Clinical variables, IHC markers, a

SUBMITTER: Kwon HR 

PROVIDER: S-EPMC9548588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature