Predictive model to identify multiple failure to biological therapy in patients with rheumatoid arthritis.

ABSTRACT:

Background

Despite advances in the treatment of rheumatoid arthritis (RA) and the wide range of therapies available, there is a percentage of patients whose treatment presents a challenge for clinicians due to lack of response to multiple biologic and target-specific disease-modifying antirheumatic drugs (b/tsDMARDs).

Objective

To develop and validate an algorithm to predict multiple failure to biological therapy in patients with RA.

Design

Observational retrospective study involving subjects from a cohort of patients with RA receiving b/tsDMARDs.

Methods

Based on the number of prior failures to b/tsDMARDs, patients were classified as either multi-refractory (MR) or non-refractory (NR). Patient characteristics were considered in the statistical analysis to desi

SUBMITTER: Novella-Navarro M 

PROVIDER: S-EPMC9549195 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature