PIFA-mediated selenylative spirocyclization of indolyl ynones: facile access to selenated spiro[cyclopentenone-1,3'-indoles].

ABSTRACT: A fast selenylative spirocyclization of indolyl ynones mediated by PIFA has been developed. This transformation was enabled by the reactive RSeOCOCF₃ species generated in situ from diselenides with PIFA, involving an electrophilic dearomative cascade cyclization. This protocol provides a facile and efficient method for the synthesis of selenated spiro[cyclopentenone-1,3'-indoles] and tolerates broad functional groups.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9549584 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature