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PIFA-mediated selenylative spirocyclization of indolyl ynones: facile access to selenated spiro[cyclopentenone-1,3′-indoles]† † Electronic supplementary information (ESI) available: Experimental details and spectral data, copies of 1H and 13C NMR spectra. See DOI: https://doi.org/10.1039/d2ra05387j

ABSTRACT: A fast selenylative spirocyclization of indolyl ynones mediated by PIFA has been developed. This transformation was enabled by the reactive RSeOCOCF3 species generated in situ from diselenides with PIFA, involving an electrophilic dearomative cascade cyclization. This protocol provides a facile and efficient method for the synthesis of selenated spiro[cyclopentenone-1,3′-indoles] and tolerates broad functional groups. A fast selenylative spirocyclization of indolyl ynones mediated by PIFA has been developed. This transformation was enabled by the reactive RSeOCOCF3 species generated in situ from diselenides with PIFA, involving an electrophilic dearomative cascade cyclization.

SUBMITTER: Chen Z

PROVIDER: S-EPMC9549584 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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