Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy.

ABSTRACT:

Propose

Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant chemotherapy treatment predicts survival. Studies have shown that patient-derived organoids can be used in cancer research and drug development. Therefore, we aimed to generate a living organoid biobank from biopsy samples to predict the response of patients to neoadjuvant chemotherapy.

Method

We generated a living organoid biobank from locally advanced breast cancer patients receiving neoadjuvant chemotherapy. When the patient received neoadjuvant chemotherapy, the organoids were treated with similar drugs, thereby simulating the situation of the patient receiving treatment.

Result

We successfully constr

SUBMITTER: Shu D 

PROVIDER: S-EPMC9549797 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature