Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19.

ABSTRACT:

Background

A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID-19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for this heterogeneity and for developing novel agents to prevent critical conditions. This study aimed to elucidate the modulations of sphingolipids and glycerophospholipids, which have been shown to possess potent biological properties.

Methods

We measured the serum sphingolipid and glycerophospholipid levels in a total of 887 samples from 215 COVID-19 subjects, plus 115 control subjects without infectious diseases and 109 subjects with infectious diseases other than COVID-19.

Results

We observed the dynamic modulations of sphingolipids

SUBMITTER: Kurano M 

PROVIDER: S-EPMC9549873 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature