Dataset Information

Diagnosis of left ventricular hypertrophy using non-ECG-gated 15O-water PET.

ABSTRACT: To develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion 15O-water positron emission tomography (PET). We retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy. 15O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and remaining scans with newer devices for a blinded evaluation. Dynamic data were converted into parametric images of perfusable tissue fraction for semi-automatic delineation of the LV wall and calculation of LV mass (LVM) and septal wall thickness (WT). LVM and WT from PET were compared to cardiac magnetic resonance (CMR, n = 47) and WT to 2D-echocardiography (2DE, n = 36). PET accuracy was tested using linear regression, Bland-Altman plots, and ROC curves. Observer reproducibility were evaluated using intraclass correlation coefficients. High correlations were found in the blinded analyses (r ≥ 0.87, P < 0.0001 for all). AUC for detecting increased LVM and WT (> 12 mm and > 15 mm) was ≥ 0.95 (P < 0.0001 for all). Reproducibility was excellent (ICC ≥ 0.93, P < 0.0001). 15O-water PET might detect LV hypertrophy with high accuracy and precision.

SUBMITTER: Sorensen J

PROVIDER: S-EPMC9553817 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Diagnosis of left ventricular hypertrophy using non-ECG-gated <sup>15</sup>O-water PET.

Sörensen Jens J Nordström Jonny J Baron Tomasz T Mörner Stellan S Granstam Sven-Olof SO Lubberink Mark M Tolbod Lars L van den Berg Jeffrey J Flachskampf Frank A FA Kero Tanja T Magnusson Peter P Harms Hendrik J HJ

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20210720 5

<h4>Aim</h4>To develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion <sup>15</sup>O-water positron emission tomography (PET).<h4>Methods</h4>We retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy. <sup>15</sup>O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and rem ...[more]

PMID: 34286452

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Project description:ObjectiveTo clinically validate the feasibility and accuracy of cine images acquired through the multitasking method, with no electrocardiogram gating and free-breathing, in measuring left ventricular (LV) function indices by comparing them with those acquired through the balanced steady-state free precession (bSSFP) method, with multiple breath-holds and electrocardiogram gating.Materials and methodsForty-three healthy volunteers (female:male, 30:13; mean age, 23.1 ± 2.3 years) and 36 patients requiring an assessment of LV function for various clinical indications (female:male, 22:14; 57.8 ± 11.3 years) were enrolled in this prospective study. Each participant underwent cardiac magnetic resonance imaging (MRI) using the multiple breath-hold bSSFP method and free-breathing multitasking method. LV function parameters were measured for both MRI methods. Image quality was assessed through subjective image quality scores (1 to 5) and calculation of the contrast-to-noise ratio (CNR) between the myocardium and blood pool. Differences between the two MRI methods were analyzed using the Bland-Altman plot, paired t-test, or Wilcoxon signed-rank test, as appropriate.ResultsLV ejection fraction (LVEF) was not significantly different between the two MRI methods (P = 0.222 in healthy volunteers and P = 0.343 in patients). LV end-diastolic mass was slightly overestimated with multitasking in both healthy volunteers (multitasking vs. bSSFP, 60.5 ± 10.7 g vs. 58.0 ± 10.4 g, respectively; P < 0.001) and patients (69.4 ± 18.1 g vs. 66.8 ± 18.0 g, respectively; P = 0.003). Acceptable and comparable image quality was achieved for both MRI methods (multitasking vs. bSSFP, 4.5 ± 0.7 vs. 4.6 ± 0.6, respectively; P = 0.203). The CNR between the myocardium and blood pool showed no significant differences between the two MRI methods (18.89 ± 6.65 vs. 18.19 ± 5.83, respectively; P = 0.480).ConclusionMultitasking-derived cine images obtained without electrocardiogram gating and breath-holding achieved similar image quality and accurate quantification of LVEF in healthy volunteers and patients.

Dataset Information

Diagnosis of left ventricular hypertrophy using non-ECG-gated 15O-water PET.

Publications

Diagnosis of left ventricular hypertrophy using non-ECG-gated <sup>15</sup>O-water PET.

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