Ontology highlight
ABSTRACT:
SUBMITTER: Hounkpe BW
PROVIDER: S-EPMC9554166 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Hounkpe Bidossessi Wilfried BW Moraes Carla Roberta Peachazepi CRP Lanaro Carolina C Santos Magnun Nueldo Nunes MNN Costa Fernando Ferreira FF De Paula Erich Vinicius EV
Experimental biology and medicine (Maywood, N.J.) 20220701 17
Hemolytic diseases such as Sickle Cell Disease (SCD) are characterized by a natural propensity for both arterial and venous thrombosis. The ability of heme to induce tissue factor (TF) activation has been shown both in animal models of SCD, and in human endothelial cells and monocytes. Moreover, it was recently demonstrated that heme can induce coagulation activation in the whole blood of healthy volunteers in a TF-dependent fashion. Herein, we aim to further explore the cellular mechanisms by w ...[more]