Stress Hyperphenylalaninemia Is Associated With Mortality in Cardiac ICU: Clinical Factors, Genetic Variants, and Pteridines.

ABSTRACT:

Objectives

Hyperphenylalaninemia predicts poor outcomes in patients with cardiovascular disease. However, the prognostic value and factors associated with stress hyperphenylalaninemia (SHP) were unknown in critical patients in the cardiac ICU.

Design

Prospective observational study.

Setting

Single-center, cardiac ICU in Taiwan.

Patients

Patients over 20 years old with Acute Physiology And Chronic Health Evaluation II scores greater than or equal to 15 and/or ventilatory support in the cardiac ICU.

Interventions

We measured plasma phenylalanine levels serially during patients' stays in the ICU to investigate their prognostic value for 90-day mortality. Gene array was performed to identify genetic polymorphisms associated with SHP (phenylalanine level ≥ 11

SUBMITTER: Wang CH 

PROVIDER: S-EPMC9555827 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature