Dataset Information

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.

ABSTRACT: Thrombosis and thromboembolism are deadly risk factors in blood-contacting biomedical devices, and in-silico models of thrombosis are attractive tools to understand the mechanics of these processes, though the simulation of thromboembolism remains underdeveloped. The purpose of this study is to modify an existing computational thrombosis model to allow for thromboembolism and to investigate the behavior of the modified model at a range of flow rates. The new and existing models are observed to lead to similar predictions of thrombosis in a canonical backward-facing step geometry across flow rates, and neither model predicts thrombosis in a turbulent flow. Simulations are performed by increasing flow rates in the case of a clot formed at lower flow to induce embolization. While embolization is observed, most of the clot breakdown is by shear rather than by breakup and subsequent transport of clotted material, and further work is required in the formulation and validation of embolization. This model provides a framework to further investigate thromboembolization.

SUBMITTER: Tobin N

PROVIDER: S-EPMC9556977 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.

Tobin Nicolas N Manning Keefe B KB

International journal for numerical methods in biomedical engineering 20220814 10

Thrombosis and thromboembolism are deadly risk factors in blood-contacting biomedical devices, and in-silico models of thrombosis are attractive tools to understand the mechanics of these processes, though the simulation of thromboembolism remains underdeveloped. The purpose of this study is to modify an existing computational thrombosis model to allow for thromboembolism and to investigate the behavior of the modified model at a range of flow rates. The new and existing models are observed to l ...[more]

PMID: 36220632

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Project description:Snow avalanches cause fatalities and economic loss worldwide and are one of the most dangerous gravitational hazards in mountainous regions. Various flow behaviors have been reported in snow avalanches, making them challenging to be thoroughly understood and mitigated. Existing popular numerical approaches for modeling snow avalanches predominantly adopt depth-averaged models, which are computationally efficient but fail to capture important features along the flow depth direction such as densification and granulation. This study applies a three-dimensional (3D) material point method (MPM) to explore snow avalanches in different regimes on a complex real terrain. Flow features of the snow avalanches from release to deposition are comprehensively characterized for identification of the different regimes. In particular, brittle and ductile fractures are identified in the different modeled avalanches shortly after their release. During the flow, the analysis of local snow density variation reveals that snow granulation requires an appropriate combination of snow fracture and compaction. In contrast, cohesionless granular flows and plug flows are mainly governed by expansion and compaction hardening, respectively. Distinct textures of avalanche deposits are characterized, including a smooth surface, rough surfaces with snow granules, as well as a surface showing compacting shear planes often reported in wet snow avalanche deposits. Finally, the MPM modeling is verified with a real snow avalanche that occurred at Vallée de la Sionne, Switzerland. The MPM framework has been proven as a promising numerical tool for exploring complex behavior of a wide range of snow avalanches in different regimes to better understand avalanche dynamics. In the future, this framework can be extended to study other types of gravitational mass movements such as rock/glacier avalanches and debris flows with implementation of modified constitutive laws.Supplementary informationThe online version contains supplementary material available at 10.1007/s10346-021-01692-8.

Dataset Information

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.

Publications

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.

Similar Datasets

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