Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.

ABSTRACT:

Objective

Disturbances in NAD⁺ metabolism have been described as a hallmark for multiple metabolic and age-related diseases, including type 2 diabetes. While alterations in pancreatic β-cell function are critical determinants of whole-body glucose homeostasis, the role of NAD⁺ metabolism in the endocrine pancreas remains poorly explored. Here, we aimed to evaluate the role of nicotinamide riboside (NR) metabolism in maintaining NAD⁺ levels and pancreatic β-cell function in pathophysiological conditions.

Methods

Whole body and pancreatic β-cell-specific NRK1 knockout (KO) mice were metabolically phenotyped in situations of high-fat feeding and aging. We also analyzed pancreatic β-cell function, β-cell mass and gene expression.

Results

W

SUBMITTER: Cercillieux A 

PROVIDER: S-EPMC9557729 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature