Construction of a prognostic model of colon cancer patients based on metabolism-related lncRNAs.

ABSTRACT:

Background

Many studies have shown that metabolism-related lncRNAs may play an important role in the pathogenesis of colon cancer. In this study, a prognostic model for colon cancer patients was constructed based on metabolism-related lncRNAs.

Methods

Both transcriptome data and clinical data of colon cancer patients were downloaded from the TCGA database, and metabolism-related genes were downloaded from the GSEA database. Through differential expression analysis and Pearson correlation analysis, long non-coding RNAs (lncRNAs) related to colon cancer metabolism were obtained. CRC patients were divided into training set and verification set at the ratio of 2:1. Based on the training set, univariate Cox regression analysis was utilized to determine the prognostic differential

SUBMITTER: Li C 

PROVIDER: S-EPMC9558288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature