Multivariate Longitudinal Modeling of Macular Ganglion Cell Complex: Spatiotemporal Correlations and Patterns of Longitudinal Change.

ABSTRACT:

Purpose

To investigate spatiotemporal correlations among ganglion cell complex (GCC) superpixel thickness measurements and explore underlying patterns of longitudinal change across the macular region.

Design

Longitudinal cohort study.

Subjects

One hundred eleven eyes from 111 subjects from the Advanced Glaucoma Progression Study with ≥ 4 visits and ≥ 2 years of follow-up.

Methods

We further developed our proposed Bayesian hierarchical model for studying longitudinal GCC thickness changes across macular superpixels in a cohort of glaucoma patients. Global priors were introduced for macular superpixel parameters to combine data across superpixels and better estimate population slopes and intercepts.

Main outcome measures

Bayesian residual analysis to inspe

SUBMITTER: Mohammadzadeh V 

PROVIDER: S-EPMC9559093 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature