Alcohol intake and bradyarrhythmia risk: a cohort study of 407 948 individuals.

ABSTRACT:

Aims

There is a paucity of epidemiological evidence on alcohol and the risk of bradyarrhythmias. We thus characterized associations of total and beverage-specific alcohol consumption with incident bradyarrhythmias using data from the UK Biobank.

Methods and results

Alcohol consumption reported at baseline was calculated as UK standard drinks (8 g alcohol)/week. Bradyarrhythmia events were defined as sinus node dysfunction (SND), high-level atrioventricular block (AVB), and permanent pacemaker implantations. Outcomes were assessed through hospitalization and death records, and dose-response associations were characterized using Cox regression models with correction for regression dilution bias. We studied 407 948 middle-aged individuals (52.4% female). Over a median follow-up

SUBMITTER: Tu SJ 

PROVIDER: S-EPMC9559907 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature