Comparing Accuracies of Length-Type Geographic Atrophy Growth Rate Metrics Using Atrophy-Front Growth Modeling.

ABSTRACT:

Purpose

To compare the accuracies of the previously proposed square-root-transformed and perimeter-adjusted metrics for estimating length-type geographic atrophy (GA) growth rates.

Design

Cross-sectional and simulation-based study.

Participants

Thirty-eight eyes with GA from 27 patients.

Methods

We used a previously developed atrophy-front growth model to provide analytical and numerical evaluations of the square-root-transformed and perimeter-adjusted growth rate metrics on simulated and semisimulated GA growth data.

Main outcome measures

Comparison of the accuracies of the square-root-transformed and perimeter-adjusted metrics on simulated and semisimulated GA growth data.

Results

Analytical and numerical evaluations showed that the accuracy of

SUBMITTER: Moult EM 

PROVIDER: S-EPMC9560575 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature