The prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer.

ABSTRACT:

Introduction

To establish the impact of the number of lymph node metastases (nLNM) and the lymph node ratio (LNR) on survival in patients with early-stage cervical cancer after surgery.

Material and methods

In this nationwide historical cohort study, all women diagnosed between 1995 and 2020 with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA2-IIA1 cervical cancer and nodal metastases after radical hysterectomy and pelvic lymphadenectomy from the Netherlands Cancer Registry were selected. Optimal cut-offs for prognostic stratification by nLNM and LNR were calculated to categorize patients into low-risk or high-risk groups. Kaplan-Meier overall survival analysis and flexible parametric relative survival analysis were used to determine the impact of

SUBMITTER: Olthof EP 

PROVIDER: S-EPMC9564443 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature