A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease.

ABSTRACT:

Background

Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão.

Methods

A retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16^INK4a, p53, and ki-67.

Results

Our data revealed a delay of 17 mont

SUBMITTER: Teixeira Junior AAL 

PROVIDER: S-EPMC9569053 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature