Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy.

ABSTRACT: Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group with a lipid diet for eight weeks followed by a standard diet and hypolipidemic treatment (atorvastatin and PCSK9 siRNA-inhibitor) for four weeks (Asi). Mass spectrometry experiments of left ventricle lysates were complemented by immunologic and gen

SUBMITTER: Suica VI 

PROVIDER: S-EPMC9569654 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature