Association of NGF and Mitochondrial Respiration with Autism Spectrum Disorder.

ABSTRACT:

Background

NGF is a molecule with a pleiotropic role, affecting neuro-immune functions, energy homeostasis, and synaptic plasticity. The mechanisms of NGF-induced neuronal differentiation are well established, but its effect on mitochondria in autism spectrum disorder (ASD) is still unclear. We hypothesize that NGF-induced neuronal development requires large amounts of energy, and mitochondria in ASD are overloaded to meet the new functional requirements.

Method

The study includes primary diagnosed ASD children. Peripheral blood mononuclear cells (PBMCs) and plasma were obtained from both patients and typically developing children (TDC). PBMCs were analyzed with Seahorse XFp, and plasma NGF protein levels were measured.

Results

We detected nearly 50% higher NGF levels

SUBMITTER: Gevezova M 

PROVIDER: S-EPMC9569874 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature