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New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S_NAr)-Synthesis and Cellular Uptake Studies.

ABSTRACT: Glycoporphyrins are group of compounds of high value for the purpose of photodynamic therapy and other biomedical applications. Despite great progress in the field, new diversity-oriented syntheses of carbohydrate-porphyrin hybrids are increasingly desired. Herein, we present efficient, mild, and metal-free conditions for synthesis of glycoporphyrins. The versatile nature of the S_NAr procedure is presented in 16 examples. Preliminary biological studies have been conducted on the cytotoxicity and cellular uptake of the final molecules.

SUBMITTER: Rosa M

PROVIDER: S-EPMC9570116 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S<sub>N</sub>Ar)-Synthesis and Cellular Uptake Studies.

Rosa Mariusz M Jędryka Natalia N Skorupska Sandra S Grabowska-Jadach Ilona I Malinowski Maciej M

International journal of molecular sciences 20220926 19

Glycoporphyrins are group of compounds of high value for the purpose of photodynamic therapy and other biomedical applications. Despite great progress in the field, new diversity-oriented syntheses of carbohydrate-porphyrin hybrids are increasingly desired. Herein, we present efficient, mild, and metal-free conditions for synthesis of glycoporphyrins. The versatile nature of the S<sub>N</sub>Ar procedure is presented in 16 examples. Preliminary biological studies have been conducted on the cytot ...[more]

PMID: 36232622

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