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ABSTRACT: Background
Data regarding the combined prognostic role of biomarkers and risk scores in relation with the history of atherosclerotic cardiovascular disease (ASCVD) in COVID-19 patients are lacking.Methods
The aim of this observational cohort study was to evaluate the combined prognostic value of N-terminal pro B-type natriuretic peptide (NT-pro BNP), troponin and risk scores in relation with ASCVD history in hospitalized COVID-19 patients. The primary composite endpoint was Intensive Care Unit (ICU) admission and death.Results
From April 2020 to June 2022, 1066 consecutive COVID-19 patients with available biomarkers upon admission were included. During a median follow-up period of 12 days, 176 patients (16.5%) died. Independent predictors of ICU admission and death in patients with ASCVD were NT-pro BNP (HR 2.63; 95% CI, 1.65-4.18) and troponin (HR 1.51; 95% CI, 1.13-2.03). In patients without ASCVD, only NT-pro BNP was predictive for the primary endpoint (HR 1.66; 95% CI, 1.10-2.53). This remained significant after adjustment for other relevant covariates (HR 3.54; 95% CI, 1.98-6.33) in patients with ASCVD and in patients without ASCVD (HR 1.82; 95% CI, 1.02-3.26).Conclusions
These data showed the combined prognostic accuracy of NT-pro BNP and troponin in relation with ASCVD history for ICU admission and death in COVID-19 patients.
SUBMITTER: Lionte C
PROVIDER: S-EPMC9571947 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Lionte Catalina C Sorodoc Victorita V Haliga Raluca Ecaterina RE Bologa Cristina C Ceasovschih Alexandr A Sirbu Oana O Gorciac Victoria V Chelariu Andrei-Costin AC Stoica Alexandra A Tocila Roxana Elena RE Badescu Minerva Codruta MC Costache Irina-Iuliana II Sandu Christiana Brigitte CB Jaba Elisabeta E Sorodoc Laurentiu L
Journal of clinical medicine 20220926 19
<h4>Background</h4>Data regarding the combined prognostic role of biomarkers and risk scores in relation with the history of atherosclerotic cardiovascular disease (ASCVD) in COVID-19 patients are lacking.<h4>Methods</h4>The aim of this observational cohort study was to evaluate the combined prognostic value of N-terminal pro B-type natriuretic peptide (NT-pro BNP), troponin and risk scores in relation with ASCVD history in hospitalized COVID-19 patients. The primary composite endpoint was Inten ...[more]