Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via ¹H-NMR-Based Approach.

ABSTRACT: Cocoa constitutes one of the richest sources of dietary flavonoids with demonstrated anti-diabetic potential. However, the metabolic impact of cocoa intake in a diabetic context remains unexplored. In this study, metabolomics tools have been used to investigate the potential metabolic changes induced by cocoa in type 2 diabetes (T2D). To this end, male Zucker diabetic fatty rats were fed on standard (ZDF) or 10% cocoa-rich diet (ZDF-C) from week 10 to 20 of life. Cocoa supplementation clearly decreased serum glucose levels, improved glucose metabolism and produced significant changes in the urine metabolome of ZDF animals. Fourteen differential urinary metabolites were identified, with eight of them significantly modified by cocoa. An analysis of pathways revealed that butanoate metabolism

SUBMITTER: Fernandez-Millan E 

PROVIDER: S-EPMC9572671 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature