Ontology highlight
ABSTRACT:
SUBMITTER: Hlavac V
PROVIDER: S-EPMC9574568 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Hlaváč Viktor V Holý Petr P Václavíková Radka R Rob Lukáš L Hruda Martin M Mrhalová Marcela M Černaj Petr P Bouda Jiří J Souček Pavel P
Life science alliance 20221013 12
Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected EOC. Compared with sensitive patients, platinum-resistant patients had a significantly higher somatic mutational rate in <i>TP53</i> and lower in several genes from the Hippo pathway. We confirmed the pivotal role of somatic mutations in homologous recombination repai ...[more]