MiR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity.

ABSTRACT: Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on a neuron respond uniformly to the same perturbation remains unclear. Moreover, the molecular determinants that underlie synapse-specific homeostatic synaptic plasticity are unknown. Here, we report a synaptic tagging mechanism in which the ability of individual synapses to increase their strength in response to activity deprivation depends on the local expression of the spine-apparatus protein synaptopodin under the regulation of miR-124. Using genetic manipulations to alter synaptopodin expression or regulation by miR-124, we show that synaptopodin behaves as a "postsynaptic tag" whose translation is derep

SUBMITTER: Dubes S 

PROVIDER: S-EPMC9574720 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature