Stable and Discriminatory Radiomic Features from the Tumor and Its Habitat Associated with Progression-Free Survival in Glioblastoma: A Multi-Institutional Study.

ABSTRACT:

Background and purpose

Glioblastoma is an aggressive brain tumor, with no validated prognostic biomarkers for survival before surgical resection. Although recent approaches have demonstrated the prognostic ability of tumor habitat (constituting necrotic core, enhancing lesion, T2/FLAIR hyperintensity subcompartments) derived radiomic features for glioblastoma survival on treatment-naive MR imaging scans, radiomic features are known to be sensitive to MR imaging acquisitions across sites and scanners. In this study, we sought to identify the radiomic features that are both stable across sites and discriminatory of poor and improved progression-free survival in glioblastoma tumors.

Materials and methods

We used 150 treatment-naive glioblastoma MR imaging scans (Gadolinium-T1w,

SUBMITTER: Verma R 

PROVIDER: S-EPMC9575418 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature