Rituximab for acute plasma-refractory thrombotic thrombocytopenic purpura: A case report.

ABSTRACT:

Introduction and importance

Thrombotic thrombocytopenic purpura (TTP) is a rare disease due to deficiency of ADAMTS13 which can present with anemia and thrombocytopenia. The study highlights the role of PLASMIC score in diagnosis and rituximab in the treatment of this condition.

Case presentation

Herein, we report a case of 38 years old female who had presented with fever, irritability, and altered sensorium. On investigations, she had hemolytic anemia, and thrombocytopenia with peripheral blood smear showing occasional schistocytes and managed with steroids and plasma exchange. As her platelet, LDH, and a few other lab parameters failed to normalize and met the criteria of refractory TTP, hence she was started on 5 cycles of rituximab and her condition improved.

Clinical

SUBMITTER: Chaurasiya PS 

PROVIDER: S-EPMC9577965 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature