Unknown

Dataset Information

0

Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.


ABSTRACT: Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae is a medically important pathogen that commonly causes human nosocomial infections. Since veterinary emergency and critical care services have also significantly progressed over the last decades, there are increasing reports of ESBL-producing K. pneumoniae causing hospital-associated infections in companion animals. We present microbiological and genomic analysis of a multidrug-resistant ESBL-positive K. pneumoniae (LCKp01) isolated from a fatal infection in a dog admitted to a veterinary intensive care unit. LCKp01 strain belonged to the sequence type ST392 and displays a KL27 (wzi-187) and O-locus 4 (O4). A broad resistome and presence of the bla CTX-M-15 ESBL gene were predicted. SNP-based phylogenomic analysis, using an international genome database, clustered LCKp01 (60-80 SNPs differences) with K. pneumoniae ST392 from human and animal infections, isolated at 4-year interval, whereas phylogeographical analysis confirmed successful expansion of ST392 as a global clone of One Health concern.

SUBMITTER: da Silva LCBA 

PROVIDER: S-EPMC9582550 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive <i>Klebsiella pneumoniae</i>: A one health clone threatening companion animals.

da Silva Luciano C B A LCBA   Cardoso Brenda B   Fontana Herrison H   Esposito Fernanda F   Cortopassi Silvia R G SRG   Sellera Fábio P FP   Lincopan Nilton N  

One health (Amsterdam, Netherlands) 20220703


Extended spectrum β-lactamase (ESBL)-producing <i>Klebsiella pneumoniae</i> is a medically important pathogen that commonly causes human nosocomial infections. Since veterinary emergency and critical care services have also significantly progressed over the last decades, there are increasing reports of ESBL-producing <i>K. pneumoniae</i> causing hospital-associated infections in companion animals. We present microbiological and genomic analysis of a multidrug-resistant ESBL-positive <i>K. pneumo  ...[more]

Similar Datasets

| S-EPMC5644516 | biostudies-literature
| S-EPMC10790997 | biostudies-literature
| S-EPMC6821978 | biostudies-literature
| S-EPMC4925667 | biostudies-literature
| S-EPMC8618658 | biostudies-literature
| S-EPMC1694011 | biostudies-literature
| S-EPMC127148 | biostudies-literature
| S-EPMC2600198 | biostudies-literature
| S-EPMC9320316 | biostudies-literature