Dataset Information

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.

ABSTRACT:

Background

Leprosy represents a long-term communicable disease resulting from Mycobacterium leprae infection. IL-17A is one of the pro-inflammatory cytokines that protects humans against many fungal and bacterial pathogens.

Objective

To investigate IL-17A (rs2275913) gene polymorphism and its circulating level in leprosy patients, and to correlate the detected results with different clinical aspects of leprosy in the investigated patients.

Methods

60 patients with leprosy, and 29 age and sex-matched volunteers were investigated for IL-17A serum level and IL-17A single nucleotide polymorphism (SNP) by ELISA and RFLP-PCR respectively.

Results

IL-17A serum level was significantly higher in leprosy patients than in controls (p=0.034), and in TL than LL (p=0.017). IL-17A (rs2275913 A/G) G allele and GG genotype were associated significantly with LL (p=0.005and 0.001 respectively). IL-17A (rs2275913 A/G) AG genotype carriers demonstrated the highest IL-17A serum levels; however, its lowest levels were found in IL-17A (rs2275913 A/G) AA genotype carriers (p=0.005). Grade 2 disability (p=0.030) and positive slit skin smear (SSS) (p=0.005) were significantly associated with IL-17A (rs2275913 A/G) GG genotype.

Study limitations

The small number of studied subjects.

Conclusions

IL -17A may have a pivotal role in leprosy pathogenesis. IL-17A (rs2275913) GG genotype plus G allele might be related to the development of LL in the Egyptian population.

SUBMITTER: Farag AGA

PROVIDER: S-EPMC9582869 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature

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Publications

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.

Farag Azza Gaber Antar AGA Labeeb Azza Zagloul AZ Gerges Amany Nagy Abdalla ANA Elshaib Mustafa Elsayed ME

Anais brasileiros de dermatologia 20220921 6

<h4>Background</h4>Leprosy represents a long-term communicable disease resulting from Mycobacterium leprae infection. IL-17A is one of the pro-inflammatory cytokines that protects humans against many fungal and bacterial pathogens.<h4>Objective</h4>To investigate IL-17A (rs2275913) gene polymorphism and its circulating level in leprosy patients, and to correlate the detected results with different clinical aspects of leprosy in the investigated patients.<h4>Methods</h4>60 patients with leprosy, ...[more]

PMID: 36153175

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Dataset Information

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.

Background

Objective

Methods

Results

Study limitations

Conclusions

Publications

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.

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