CASA: a comprehensive database resource for the COVID-19 Alternative Splicing Atlas.

ABSTRACT:

Background

As a key process in transcriptional regulatory mechanisms, alternative splicing (AS) plays a crucial role in maintaining the diversity of RNA and protein expression, and mediates the immune response in infectious diseases, especially for the COVID-19. Therefore, urgent data gathering and more research of AS profiles in microbe-infected human cells are needed to improve understanding of COVID-19 and related infectious diseases. Herein, we have created CASA, the COVID-19 Alternative Splicing Atlas to provide a convenient computing platform for studies of AS in COVID-19 and COVID-19-related infectious diseases.

Methods

In CASA, we reanalyzed thousands of RNA-seq datasets generated from 65 different tissues, organoids and cell lines to systematically obtain quantitati

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9583055 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature