β-catenin ISGylation promotes lipid deposition and apoptosis in ethanol-stimulated liver injury models.

ABSTRACT:

Background

The restoration of the Wnt/β-catenin pathway to alleviate alcoholic fatty liver disease (AFLD) progression is under study as a new strategy for alcoholic liver disease (ALD) treatment. Recent studies have indicated that interferon-stimulated gene 15 (ISG15) can covalently bind to β-catenin by HECT E3 ubiquitin ligase 5 (HERC5), leading to ISG degradation and downregulation of β-catenin levels. However, the relationship between β-catenin and the ISG15 system in AFLD remains unclear.

Methods

Here, we explored the roles of the ISG15 system in β-catenin activation and in the pathogenesis of alcohol-induced liver injury and steatosis.

Results

In this study, HERC5 silencing upregulated β-catenin protein expression and inhibited lipid metabolism disorders and cell

SUBMITTER: Ding Q 

PROVIDER: S-EPMC9586657 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature