Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice.

ABSTRACT: The number and quality of oocytes in the ovarian reserve are related to fertility and reproductive lifespan in mammals. Some transcription factors have been demonstrated to determine oogenesis. The insulinoma-associated 2 (Insm2) gene is a member of the Snail transcriptional repressor superfamily. Recent studies have demonstrated Insm2 plays an essential role for insulin secretion and glucose intolerance in mice, but the functions of Insm2 in reproduction remain elusive. Here, by examination of Insm2 knockout mice, we found Insm2 was essential for female fertility. Loss of Insm2 resulted in female infertility with major defects in primordial follicle pool, ovarian folliculogenesis and ovulation. Transcriptomic profiling of ovaries suggests that los

SUBMITTER: Li ZM 

PROVIDER: S-EPMC9586662 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature